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MeSH Review

Chemistry, Pharmaceutical

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Disease relevance of Chemistry, Pharmaceutical


High impact information on Chemistry, Pharmaceutical

  • New approaches to broaden this window exploit alternative drug formulations, pharmacokinetic profiling and new immunosuppressive agents, such as Rapamycin and Brequinar, which act in a synergistic fashion [2].
  • Drug formulation and salivary phenytoin measurements [3].
  • RESULTS: Plasma clearance and elimination half-lives for ephedrine, pseudoephedrine, and caffeine were comparable to published values reported for drug formulations [4].
  • A tumor model designed to assess liposome-mediated drug delivery to liver has been used in an attempt to better understand the mechanism of activity of liposomal mitoxantrone, a liposomal anticancer drug formulation that appears to be uniquely effective in treating this tumor model [5].
  • In this report, the performance of these nitrate drug/formulation combinations is discussed in terms of the relative onset of action, duration of action, tolerance properties/regeneration of reactivity and patient acceptance [6].

Biological context of Chemistry, Pharmaceutical


Anatomical context of Chemistry, Pharmaceutical


Associations of Chemistry, Pharmaceutical with chemical compounds


Gene context of Chemistry, Pharmaceutical


Analytical, diagnostic and therapeutic context of Chemistry, Pharmaceutical


  1. SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Giles, F.J., Stopeck, A.T., Silverman, L.R., Lancet, J.E., Cooper, M.A., Hannah, A.L., Cherrington, J.M., O'Farrell, A.M., Yuen, H.A., Louie, S.G., Hong, W., Cortes, J.E., Verstovsek, S., Albitar, M., O'Brien, S.M., Kantarjian, H.M., Karp, J.E. Blood (2003) [Pubmed]
  2. Immunosuppressive therapy. Kahan, B.D. Curr. Opin. Immunol. (1992) [Pubmed]
  3. Drug formulation and salivary phenytoin measurements. Ayers, G.J., Burnett, D. Lancet (1977) [Pubmed]
  4. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Haller, C.A., Jacob, P., Benowitz, N.L. Clin. Pharmacol. Ther. (2002) [Pubmed]
  5. Kupffer cells do not play a role in governing the efficacy of liposomal mitoxantrone used to treat a tumor model designed to assess drug delivery to liver. Lim, H.J., Parr, M.J., Masin, D., McIntosh, N.L., Madden, T.D., Zhang, G., Johnstone, S., Bally, M.B. Clin. Cancer Res. (2000) [Pubmed]
  6. Nitrate therapy: is there an optimal substance and formulation? Fung, H.L. Eur. Heart J. (1991) [Pubmed]
  7. Potential role of the low-density lipoprotein receptor family as mediators of cellular drug uptake. Chung, N.S., Wasan, K.M. Adv. Drug Deliv. Rev. (2004) [Pubmed]
  8. A corneal perfusion device for estimating ocular bioavailability in vitro. Richman, J.B., Tang-Liu, D.D. Journal of pharmaceutical sciences. (1990) [Pubmed]
  9. Pharmacokinetics of verapamil and its metabolite norverapamil from a buccal drug formulation. Sawicki, W., Janicki, S. International journal of pharmaceutics. (2002) [Pubmed]
  10. Plasma levels of 13,14-dihydro-15-keto PGE2 after vaginal application of a new PGE2 film. Prasad, R.N., Roy, A.C., Kottegoda, S.R., Ratnam, S.S., Karim, S.M. Prostaglandins (1985) [Pubmed]
  11. Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits. Sznitowska, M., Gajewska, M., Janicki, S., Radwanska, A., Lukowski, G. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2001) [Pubmed]
  12. Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line. Serpe, L., Catalano, M.G., Cavalli, R., Ugazio, E., Bosco, O., Canaparo, R., Muntoni, E., Frairia, R., Gasco, M.R., Eandi, M., Zara, G.P. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2004) [Pubmed]
  13. Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of docetaxel and paclitaxel in human plasma and oral fluid. Mortier, K.A., Renard, V., Verstraete, A.G., Van Gussem, A., Van Belle, S., Lambert, W.E. Anal. Chem. (2005) [Pubmed]
  14. Rapid and selective micellar electrokinetic chromatography for simultaneous determination of amikacin, kanamycin A, and tobramycin with UV detection and application in drug formulations. Yeh, H.H., Lin, S.J., Ko, J.Y., Chou, C.A., Chen, S.H. Electrophoresis (2005) [Pubmed]
  15. Removal of acetaldehyde from saliva by a slow-release buccal tablet of L-cysteine. Salaspuro, V., Hietala, J., Kaihovaara, P., Pihlajarinne, L., Marvola, M., Salaspuro, M. Int. J. Cancer (2002) [Pubmed]
  16. Supercritical fluid extraction of active components in a drug formulation. Mulcahey, L.J., Taylor, L.T. Anal. Chem. (1992) [Pubmed]
  17. Pharmacokinetics of zidovudine administered intravenously and orally in children with human immunodeficiency virus infection. Balis, F.M., Pizzo, P.A., Eddy, J., Wilfert, C., McKinney, R., Scott, G., Murphy, R.F., Jarosinski, P.F., Falloon, J., Poplack, D.G. J. Pediatr. (1989) [Pubmed]
  18. Analysis of piperazine drug formulations for N-nitrosamines. Dawson, B.A., Lawrence, R.C. Journal - Association of Official Analytical Chemists. (1987) [Pubmed]
  19. Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats. Ten Hagen, T.L., Van Der Veen, A.H., Nooijen, P.T., Van Tiel, S.T., Seynhaeve, A.L., Eggermont, A.M. Int. J. Cancer (2000) [Pubmed]
  20. Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. Labiris, N.R., Dolovich, M.B. British journal of clinical pharmacology. (2003) [Pubmed]
  21. Analysis of recombinant human erythropoietin in drug formulations by high-performance capillary electrophoresis. Bietlot, H.P., Girard, M. Journal of chromatography. A. (1997) [Pubmed]
  22. Pharmacokinetics of thymosin alpha1 after subcutaneous injection of three different formulations in healthy volunteers. Rost, K.L., Wierich, W., Masayuki, F., Tuthill, C.W., Horwitz, D.L., Herrmann, W.M. International journal of clinical pharmacology and therapeutics. (1999) [Pubmed]
  23. A rapid isocratic high-performance liquid chromatography method for determination of cholesterol and 1,2-dioleoyl-sn-glycero-3-phosphocholine in liposome-based drug formulations. Singh, R., Ajagbe, M., Bhamidipati, S., Ahmad, Z., Ahmad, I. Journal of chromatography. A. (2005) [Pubmed]
  24. Intralesional fluorouracil/epinephrine injectable gel for treatment of condylomata acuminata. A phase 3 clinical study. Swinehart, J.M., Sperling, M., Phillips, S., Kraus, S., Gordon, S., McCarty, J.M., Webster, G.F., Skinner, R., Korey, A., Orenberg, E.K. Archives of dermatology. (1997) [Pubmed]
  25. Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodine. Wutzler, P., Sauerbrei, A., Klöcking, R., Brögmann, B., Reimer, K. Antiviral Res. (2002) [Pubmed]
  26. Tramadol encapsulated into polyhydroxybutyrate microspheres: in vitro release and epidural analgesic effect in rats. Salman, M.A., Sahin, A., Onur, M.A., Oge, K., Kassab, A., Aypar, U. Acta anaesthesiologica Scandinavica. (2003) [Pubmed]
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