Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Paget's Disease, Mammary

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Disease relevance of Paget's Disease, Mammary

Our studies show that anti-CK7 is an effective but not 100% sensitive marker for Paget cells, staining 21 of 22 cases of mammary Paget's disease and 19 of 22 cases of extramammary Paget's disease, whereas CK20 stained 0 of 17 cases of mammary Paget's disease and 6 of 19 cases of extramammary Paget's disease [1].
This study compares the diagnostic reliability of conventional mucin histochemistry and immunocytochemical techniques in distinguishing mammary Paget's disease from superficial spreading malignant melanoma and primary intraepidermal carcinoma [2].

High impact information on Paget's Disease, Mammary

In mammary Paget's disease, positive immunoreactions for Her2/neu, AR and ER were observed in 56 of 58 (97%), 51 of 58 (88%), and respectively in six of 58 (10%) cases [3].
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease [4].
We conclude that CAM 5.2 and 21N should be used in the investigation of mammary Paget's disease in preference to conventional mucin stains [2].
Diastase-resistant PAS positivity was seen in six of 13 cases of mammary Paget's disease and eight of 13 cases using an alcian blue counterstain [2].
Overexpression of HER-2/neu was demonstrated in all five cases of mammary Paget disease [5].

Chemical compound and disease context of Paget's Disease, Mammary

Formalin-fixed, paraffin-embedded tissue from 20 cases of mammary Paget disease were analyzed for HER-2 status by IHC and FISH [6].
These results suggest that the cytoplasmic mucin in Paget cells is sialomucin without side-chain substituent in genital Paget's disease, and that with a substituent at C7 in mammary Paget's disease [7].

Gene context of Paget's Disease, Mammary

Three immunohistochemical labelling patterns were identified: (I) All six cases of mammary Paget's disease were positive for anti-HMFG and negative with monoclonal anti-CEA (although they stained to a variable degree with polyclonal anti-CEA) [8].
Earlier studies have suggested that 100% of the tumor cells in mammary Paget disease show overexpression of HER-2 protein [6].

References

Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Lundquist, K., Kohler, S., Rouse, R.V. Am. J. Surg. Pathol. (1999) [Pubmed]
Routine diagnosis of mammary Paget's disease. A modern approach. Hitchcock, A., Topham, S., Bell, J., Gullick, W., Elston, C.W., Ellis, I.O. Am. J. Surg. Pathol. (1992) [Pubmed]
Androgen receptors are frequently expressed in mammary and extramammary Paget's disease. Liegl, B., Horn, L.C., Moinfar, F. Mod. Pathol. (2005) [Pubmed]
The ectopic expression of gastric mucin in extramammary and mammary Paget's disease. Kondo, Y., Kashima, K., Daa, T., Fujiwara, S., Nakayama, I., Yokoyama, S. Am. J. Surg. Pathol. (2002) [Pubmed]
HER-2/neu expression in Paget disease of the vulva and the female breast. Brummer, O., Stegner, H.E., Böhmer, G., Kühnle, H., Petry, K.U. Gynecol. Oncol. (2004) [Pubmed]
Assessment of Her-2/Neu status by immunohistochemistry and fluorescence in situ hybridization in mammary Paget disease and underlying carcinoma. Anderson, J.M., Ariga, R., Govil, H., Bloom, K.J., Francescatti, D., Reddy, V.B., Gould, V.E., Gattuso, P. Appl. Immunohistochem. Mol. Morphol. (2003) [Pubmed]
Histochemical analysis of sialomucin in Paget cells of mammary and extramammary Paget's disease. Inokuchi, K., Sasai, Y. Acta Histochem. (1992) [Pubmed]
Immunohistochemical study of mammary and extra-mammary Paget's disease. Vanstapel, M.J., Gatter, K.C., De Wolf-Peeters, C., Millard, P.R., Desmet, V.J., Mason, D.Y. Histopathology (1984) [Pubmed]

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