Disease relevance of Glossitis

• Biochemical deficiency of riboflavin and pyridoxine was marginally higher in children with angular stomatitis with or without associated glossitis, than in children without oral lesions [1].
• Two events (dyspepsia and mouth ulceration) in the etodolac SR group and 4 events (headache, glossitis, depression and insomnia) in the diclofenac SR group were considered to be definitely drug-related [2].
• Subjects with overt atrophic glossitis (%NPD < 50%) tended to have multiple nutritional deficiencies [3].

High impact information on Glossitis

• Treatment with parenteral cobalamin reversed the clinical and hematological manifestations of the disease but she developed glossitis when the interval between injections was lengthened [4].
• The atrophic glossitis was related to reduced weight, body mass index, triceps skinfold thickness, arm-muscle circumference, muscular strength, activities of daily living and serum concentrations of cholesterol, ascorbic acid, cholecalcidiol and B12, but not to levels of zinc or folate [5].
• Nutritional correlates of atrophic glossitis: possible role of vitamin E in papillary atrophy [3].
• A 39-year-old woman presented with mild anemia, glossitis, an increased MCV, a low serum cobalamin (Cbl) (vitamin B12), mild tissue deficiency of Cbl, but with neither malabsorption of Cbl, impaired intake, nor deficiency of or inactivity of transcobalamin II (TC II) [6].
• 5. Results suggest that while glossitis is a relatively early manifestation of riboflavin or pyridoxine deficiency or both, angular stomatitis has a more complex aetiology perphaps associated with infection [1].

Chemical compound and disease context of Glossitis

• The glossitis, treated with viscous lidocaine, resolved over a three-week period [7].
• Salicylic acid in alcohol in the treatment of benign superficial migratory glossitis [8].
• Patients with median rhomboid glossitis were classified in different stages of the Centers for Disease Control 1986 classification system and showed an average of CD+4 cell counts 397.5/mm3 [9].

Biological context of Glossitis

• Its diagnosis can be enhanced if the clinician recognizes the associated clinical features of nonspecific symptoms, glossitis, and dermatologic and neuropsychiatric abnormalities, and realizes the limitations of various tests (serum B12 assay, parietal cell and intrinsic factor antibody, mean corpuscular volume, and Schilling tests) [10].

Gene context of Glossitis

• Median rhomboid glossitis associated with amyloid deposition [11].
• Granulomatous glossitis as an unusual manifestation of Melkersson-Rosenthal syndrome [12].
• Diabetic subjects with median rhomboid glossitis were more likely to have a longer duration of IDDM and complications of nephropathy and retinopathy [13].

Analytical, diagnostic and therapeutic context of Glossitis

• When patients present with a red, smooth tongue, Hunter's glossitis (which can easily be improved by administration of vitamin B12) should be considered in the differential diagnosis [14].

References