Disease relevance of Geniculate Bodies

• Kainic acid microinjection into a unilateral occipital cortex or lateral geniculate body in unanesthetized cats: models of generalized epilepsy and photic epilepsy [1].

High impact information on Geniculate Bodies

• IGFBP5 and IGF-I mRNAs are synchronously coexpressed in principal neurons of sensory relay systems, including the olfactory bulb, medial and dorsal lateral geniculate bodies, and ventral tier, cochlear, lemniscal, and vestibular nuclei [2].
• Our results showed that reserpine induced a statistically significant (except for medial geniculate body) decrease in the rate of 5-HT synthesis in a large number of discrete brain structures [3].
• Corticothalamic projections from cortical auditory field to the medial geniculate body (MG) in the rat were systematically examined by making small injections of biocytin in cortical area Te1 [4].
• We recorded simultaneously in the ventral division of the medial geniculate body (MGBv) and in primary auditory cortex (AI) of the ketamine-anesthetized cat [5].
• A study of neurons and processes (puncta) immunolabeled by antibodies to gamma-aminobutyric acid (GABA) or glutamic acid decarboxylase was undertaken in the medial geniculate body of the adult cat [6].

Biological context of Geniculate Bodies

• We examined whether the NMDA class of excitatory amino acid receptors contribute to synaptic transmission in the pathway connecting the medial geniculate body (MGB) with the lateral nucleus of the amygdala (LA) using extracellular single unit recordings and microiontophoresis [7].
• Expression of immediate early genes (IEGs; c-fos and NGFI-A) was observed in the cortex, thalamic nuclei, subthalamic nucleus, pars reticulata of the substantia nigra, lateral and medial geniculate bodies on the ipsilateral side from 3 to 15 h after FeCl2 injection [8].
• Chemical divisions in the medial geniculate body and surrounding paralaminar nuclei of the rat: quantitative comparison of cell density, NADPH diaphorase, acetyl cholin esterase and basal expression of c-fos [9].

Anatomical context of Geniculate Bodies

• These results support a role of the serotoninergic dorsal raphe projection to the lateral geniculate body and to the superior colliculus in the processing of visual information, and they suggest that serotonin may have a coordinating influence on primary visual centers [10].
• Injection of biocytin into the inferior colliculus consistently resulted in extensive anterograde labelling of axonal trunks and terminals in the ipsilateral medial geniculate body and in the contralateral inferior colliculus [11].
• In the auditory thalamus, nearly every cell in the medial geniculate body was cabp(+), but those in the suprageniculate nucleus and in the posterior group did not stain [12].
• Significant deviations were found in the primary visual cortex and, even more so, in the lateral geniculate body and the mitral cells of the olfactory bulb [13].
• Bilateral locus coeruleus (LC) lesions do not significantly alter NE content in these nuclei but do decrease NE content in the superior and inferior colliculi, medial geniculate body, interpeduncular nucleus, pontine nuclei and the main sensory trigeminal nucleus (60-75%) [14].

Associations of Geniculate Bodies with chemical compounds

• The projection from the ventral lateral geniculate body to the superior colliculus, on the other hand, comes from cells which do not stain for gamma-aminobutyric acid transaminase and therefore do probably not use gamma-aminobutyric acid as their transmitter [15].
• Photosensitivity was acquired as a result of kindling in the lateral geniculate body (GL), and the GL-kindled cat pretreated with DL-allylglycine showed a stable level of photosensitivity [16].
• Intraventricular kainic acid also caused severe selective neuron damage in the hippocampal CA3 region, limbic lobe and medial geniculate body [17].
• The most striking finding was a marked 2-deoxyglucose labeling of the dorsal lateral geniculate body and of cortical regions that correspond to visual areas in sighted rodents [18].
• The effect of diazepam on nystagmus induced by stimulation of the lateral geniculate body in the rabbit [19].

Gene context of Geniculate Bodies

• Cholecystokinin affects the neuronal discharge mode in the rat lateral geniculate body [20].
• Neuropeptide Y (NPY) that is released from the intergeniculate leaflet of the lateral geniculate body to the SCN, acts in the SCN to advance circadian phase in the subjective day via the NPY Y2 receptor [21].
• In situ hybridization for mRNA encoding estrogen receptor beta and progesterone receptor was carried out on sections containing the lateral geniculate body using [35S]-labeled antisense riboprobes [22].
• The abnormal calcium accumulation was found in the dorsolateral part of striatum, the hippocampal CA1 sector, the thalamus, the medial geniculate body, the substantia nigra and the inferior colliculus [23].
• However, calbindin and calretinin also show low levels of staining in the ventral nuclear complex and in the medial and lateral geniculate bodies which overlaps with the intense parvalbumin staining in these regions [24].

Analytical, diagnostic and therapeutic context of Geniculate Bodies

• The rats with transplants whose neurons displayed responses to visual stimulations contained in the lateral geniculate body neurons with FluoroGold-labeled cytoplasm and Bisbenzimide-labeled nuclei [25].
• The commonly-used tracers biocytin, dextran rhodamine B, FluoroGold, True Blue or rhodamine latex microspheres were injected into the medial geniculate body or the inferior colliculus of the adult rat brain explant [11].
• Changes in the activity of monoamine oxidase (MAO) and acetylcholinesterase (AChE) following unilateral eye enucleation were measured for the superior colliculus (SC), lateral geniculate body (LGB), and nucleus suprachiasmaticus (NSC) in the rat by means of microspectrophotometry [26].
• Unilateral lesions were placed in either the lateral geniculate body or the basal forebrain of rats postnatal days 8 (P8) to adulthood; the effects of these lesions on patterns of AChE activity in visual cortex were studied with histochemical techniques and optical densitometry [27].

References