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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Erythrocyte Volume

 
 
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Disease relevance of Erythrocyte Volume

 

High impact information on Erythrocyte Volume

  • In the renal-transplant recipients, red-cell mass was also reduced after eight weeks of theophylline (from 3197 +/- 82 ml at base line to 2273 +/- 69 ml after treatment; P less than 0.05) [6].
  • Haematological indices remained steady during the placebo phase, but during the medroxyprogesterone-acetate phase fetal haemoglobin, total haemoglobin, red-cell mass, and red-cell survival rose significantly, and reticulocytes, irreversibly-sickled-cell counts, and total bilirubin fell significantly [7].
  • There was no significant change in serum iron or transferrin levels, hematocrit, or red cell mass in five of the six patients [8].
  • Histidine supplementation may raise serum amino acid levels, but does not cause any increase in red cell mass or improve the anemia in patients on chronic dialysis who are ingesting adequate dietary protein [8].
  • Residual red cell mass, quantified in the outer medullary vasculature of perfusion-fixed kidneys and presumably reflecting stasis, was substantially increased in iothalamate treated rats [9].
 

Chemical compound and disease context of Erythrocyte Volume

 

Biological context of Erythrocyte Volume

 

Anatomical context of Erythrocyte Volume

  • At this time, it appears that overexpression of granulocyte PRV-1 in the presence of an elevated red cell mass supports a diagnosis of PV; absence of PRV-1 expression, however, should not be grounds for excluding PV as a diagnostic possibility [16].
  • Erythropoietin lack results in severe and often transfusion-dependent anemia but if bone marrow function is otherwise normal, recombinant human erythropoietin therapy can restore the red cell mass and alleviate the transfusion need [17].
 

Associations of Erythrocyte Volume with chemical compounds

  • After androgen therapy, six patients demonstrated more than a fivefold increase in urinary erythropoietin, with an increase in red cell mass ranging from 17%-75% above the control value [18].
  • The effect of enalapril on red cell mass results from reducing erythropoietin production [2].
  • No significant change was noted in VO2, or lactate, after augmentation of red cell mass [19].
  • The red cell mass to be exchanged (50%) was determined from the calculated increase in O2 delivery capacity required to maintain an O2 extraction of 4 to 5 mL of O2 per dL of whole blood [20].
  • The FDA-20 appeared to affect organ function and cells adversely as reflected by a fall in red cell mass and platelet levels and by a rise in liver enzymes, BUN, and serum creatinine [21].
 

Gene context of Erythrocyte Volume

  • This effect of EPO on eNOS may be a physiologically relevant mechanism to counterbalance the hypertensive effects of increased hemoglobin-related NO destruction resulting from hypoxia-induced increased red cell mass [22].
  • The hypothesis is proposed that the normal hemoglobin found in most patients with COPD is a result of a balance between a trend towards a decreased red cell mass, as found in chronic diseases, and a trend towards an increased red cell mass due to the erythropoietic effect of EPO [23].
  • In nonanemic TX patients both EPO and TfR ranged normally, whereas in anemic TX ones (Hct < 40%) both values were increased suggesting the physiologic response both of the kidney and of the erythron to decreased red cell mass [24].
  • Physiologic adjustments and the hematopoietic response to reduced red cell mass were greater in the 2-unit group, but the donation of 1 unit or 2 units did not cause detectable symptoms of reduced oxygen-carrying capacity [25].
  • Red cell mass responses to daily erythropoietin and iron injections in the ovine fetus [26].
 

Analytical, diagnostic and therapeutic context of Erythrocyte Volume

References

  1. Treatment of orthostatic hypotension with erythropoietin. Hoeldtke, R.D., Streeten, D.H. N. Engl. J. Med. (1993) [Pubmed]
  2. Correction of posttransplant erythrocytosis with enalapril. Rell, K., Koziak, K., Jarzyo, I., Lao, M., Gaciong, Z. Transplantation (1994) [Pubmed]
  3. Pathogenesis of respiratory failure (ARDS) after hemorrhage and trauma: I. Cardiorespiratory patterns preceding the development of ARDS. Shoemaker, W.C., Appel, P., Czer, L.S., Bland, R., Schwartz, S., Hopkins, J.A. Crit. Care Med. (1980) [Pubmed]
  4. Unexpected vascular response to epinephrine in port wine stains. Smoller, B.R., Kwan, T.H., Noe, J.M. Plast. Reconstr. Surg. (1987) [Pubmed]
  5. Clinicopathology and histochemistry on bone marrow biopsies in chronic myeloproliferative disorders--a clue to diagnosis and classification. Thiele, J., Kvasnicka, H.M. Pathol. Biol. (2001) [Pubmed]
  6. Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation. Bakris, G.L., Sauter, E.R., Hussey, J.L., Fisher, J.W., Gaber, A.O., Winsett, R. N. Engl. J. Med. (1990) [Pubmed]
  7. Medroxyprogesterone acetate and homozygous sickle-cell disease. De Ceulaer, K., Gruber, C., Hayes, R., Serjeant, G.R. Lancet (1982) [Pubmed]
  8. Failure of histidine supplementation to improve anemia in chronic dialysis patients. Reeves, R.D., Barbour, G.L., Robertson, C.S., Crumb, C.K. Am. J. Clin. Nutr. (1977) [Pubmed]
  9. Early renal medullary hypoxic injury from radiocontrast and indomethacin. Heyman, S.N., Brezis, M., Epstein, F.H., Spokes, K., Silva, P., Rosen, S. Kidney Int. (1991) [Pubmed]
  10. Autoregulation of erythropoiesis by 2,3 diphosphoglycerate during hyperalimentation. Petersen, S.R., Sheldon, G.F., Carpenter, G. The Journal of trauma. (1980) [Pubmed]
  11. Erythropoietin in diabetic macular edema and renal insufficiency. Friedman, E.A., Brown, C.D., Berman, D.H. Am. J. Kidney Dis. (1995) [Pubmed]
  12. Determinants of haemoglobin level in steady-state homozygous sickle cell disease. Serjeant, G., Serjeant, B., Stephens, A., Roper, D., Higgs, D., Beckford, M., Cook, J., Thomas, P. Br. J. Haematol. (1996) [Pubmed]
  13. The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Rice, L., Alfrey, C.P. Cell. Physiol. Biochem. (2005) [Pubmed]
  14. Correlation between 2,3-diphosphoglycerate and red cell mass in the third trimester of pregnancy. Tsai, C.H., de Leeuw, N.K. Acta obstetricia et gynecologica Scandinavica. (1985) [Pubmed]
  15. Characterization of the anaemia of chronic renal failure and the mode of its correction by a preparation of human erythropoietin (r-HuEPO). An investigation of the pharmacokinetics of intravenous erythropoietin and its effects on erythrokinetics. Cotes, P.M., Pippard, M.J., Reid, C.D., Winearls, C.G., Oliver, D.O., Royston, J.P. Q. J. Med. (1989) [Pubmed]
  16. Chronic myeloproliferative disorders. Spivak, J.L., Barosi, G., Tognoni, G., Barbui, T., Finazzi, G., Marchioli, R., Marchetti, M. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. (2003) [Pubmed]
  17. Erythropoietin use and abuse: When physiology and pharmacology collide. Spivak, J.L. Adv. Exp. Med. Biol. (2001) [Pubmed]
  18. Oxymetholone treatment for sickle cell anemia. Alexanian, R., Nadell, J. Blood (1975) [Pubmed]
  19. Cardiovascular and metabolic response to red blood cell transfusion in critically ill volume-resuscitated nonsurgical patients. Dietrich, K.A., Conrad, S.A., Hebert, C.A., Levy, G.L., Romero, M.D. Crit. Care Med. (1990) [Pubmed]
  20. The presurgical management with erythrocytapheresis of a patient with a high-oxygen-affinity, unstable Hb variant (Hb Bryn Mawr). Larson, P.J., Friedman, D.F., Reilly, M.P., Kattamis, A.C., Asakura, T., Fortina, P., Cohen, A.R., Kim, H.C., Manno, C.S. Transfusion (1997) [Pubmed]
  21. Role of Fluosol-DA 20% in prehospital resuscitation. Elliott, L.A., Ledgerwood, A.M., Lucas, C.E., McCoy, L.E., McGonigal, M., Sullivan, M.W. Crit. Care Med. (1989) [Pubmed]
  22. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Beleslin-Cokic, B.B., Cokic, V.P., Yu, X., Weksler, B.B., Schechter, A.N., Noguchi, C.T. Blood (2004) [Pubmed]
  23. Erythropoietin in chronic obstructive pulmonary disease. Relationship between serum erythropoietin, blood hemoglobin and lung function--effect of the calcium antagonist isradipine on serum erythropoietin. Graudal, N., Galløe, A.M., Nielsen, O.J. Respiration; international review of thoracic diseases. (1991) [Pubmed]
  24. The determination of plasma transferrin receptor as good index of erythropoietic activity in renal anemia and after renal transplantation. de Paoli Vitali, E., Ricci, G., Perini, L., Malacarne, F., Vedovato, M., Guerra, G., Dapporto, M., Gilli, P. Nephron (1996) [Pubmed]
  25. A randomized, double-blind comparison of donor tolerance of 400 mL, 200 mL, and sham red cell donation. Smith, K.J., James, D.S., Hunt, W.C., McDonough, W., Quintana, R. Transfusion (1996) [Pubmed]
  26. Red cell mass responses to daily erythropoietin and iron injections in the ovine fetus. Zhang, L., Alexander, R.L., Widness, J.A., Cheung, C.Y., Brace, R.A. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  27. Anesthesia for radical prostatectomy. Filimonovic, J., Gvozdic, B., Krivic, B., Acimovic, M., Tulic, C., Hadzi Djokic, J. Acta chirurgica Iugoslavica. (2005) [Pubmed]
  28. Red cell mass, spleen size and plasma erythropoietin in polycythaemia vera and apparent polycythaemia. Johansson, P., Safai-Kutti, S., Lindstedt, G., Suurküla, M., Kutti, J. Acta Haematol. (2002) [Pubmed]
 
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