Disease relevance of Dipodomys

• Hemorrhagic gastritis was observed in 16 of 131 Townsend's ground squirrels (Spermophilus townsendii), one of 11 Ord's kangaroo rats (Dipodomys ordii) and the one Great Basin pocket mouse (Perognathus parvus) evaluated [1].

High impact information on Dipodomys

• Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues [2].
• A study of the distribution of Topoisomerase II alpha (Topo II) in cells of six tissue culture cell lines, human (HeLa), mouse (L929), rat, Indian muntjac, rat kangaroo (PTK-2), and wallaby revealed the following features: (1) There is a cell cycle association of a specific population of Topo II with the centromere [3].
• During our studies with antibodies against structural proteins of the cytoskeleton of eukaryotic cells we have observed that sera from many normal rabbits decorate a fiber system in cells of the established rat kangaroo cell line Pt K2 [4].
• We have examined structural changes induced by amsacrine and other intercalators (actinomycin D, Adriamycin, mitoxantrone, 9-aminoacridine) in cultured Chinese hamster (V79-171b) and rat kangaroo kidney epithelial (PtK2) cells, using light- and electron microscopy with simultaneous assessment of cell survival [5].
• S phase patterns of replication of different satellite DNAs in three species of Dipodomys (kangaroo rat) [6].

Anatomical context of Dipodomys

• We report that AQP4 forms OAPs in rat gastric parietal cells but not in parietal cells from the mouse or kangaroo rat [7].
• To obtain accurate et plentiful measurements, a 'flow-fixation' technique was devised, which flattens the long primary cilia of cultured PtK1 cells (a kidney epithelial cell line from Potorous tridactylus, the kangaroo rat), prior to immunostaining with an antibody directed against detyrosinated tubulin (ID5) [8].
• Vasoconstrictors alter oxygen, lactate, and glycerol metabolism in the perfused hindlimb of a rat kangaroo [9].
• These antibodies were used to stain cultured cells of various tissues (epithelium, nervous tissue, fibroblasts) from different animals (human, monkey, pig, rat, kangaroo rat, mouse, hamster, chicken, triton) [10].

Associations of Dipodomys with chemical compounds

• Effects of amsacrine and other DNA-intercalating drugs on nuclear and nucleolar structure in cultured V79 Chinese hamster cells and PtK2 rat kangaroo cells [5].
• In response to thyroxine. kangaroo rats increased food consumption only slightly, but this small increase was sufficient to compensate for their elevated metabolic rates [11].
• Regulation of plasma antidiuretic hormone in the dehydrated kangaroo rat (Dipodomys spectabilis M.) [12].
• The nucleolar organisation has been studied in cycloheximide treated rat kangaroo cells [13].
• Laser microbeam irradiation of rat kangaroo cells (PTK2) following selective sensitization with bromodeoxyuridine and ethidium bromide [14].

Gene context of Dipodomys

• These results suggest that renal expression of AQP4 in the kangaroo rat kidney is regulated at the transcriptional or translational level, and the absence of AQP4 may be critical for the extreme urinary concentration that occurs in this species [15].
• This cell line, which is derived from rat kangaroo, contains a profilin sharing an N-terminal epitope with bovine and human profilin I, as seen by immunoblotting with monoclonal antibodies [16].

References