Disease relevance of Visna-Maedi Virus

• Infection by lentiviruses such as human immunodeficiency virus, Maedi-Visna virus and Caprine Arthritis Encephalitis Virus, is associated with a variety of neurological syndromes, but the mechanism by which the damage occurs to the nervous system is not known [1].
• Conserved sequence motifs involving the tat reading frame of Brazilian caprine lentiviruses indicate affiliations to both caprine arthritis-encephalitis virus and visna-maedi virus [2].
• We studied the biological and biochemical properties of CAEV and maedi-visna virus (MVV) of sheep following inoculation into the three ovine/caprine cell types [3].
• Maedi-visna has never been recorded in Australia. However, caprine retroviruses have been isolated which cause clinical disease similar to caprine arthritis-encephalitis and produce antibodies in goats similar to those caused by maedi-visna virus [4].
• Virus particles, morphologically indistinguishable from maedi-visna virus or caprine arthritis-encephalitis virus, were detected in tissue explant cultures prepared post mortem from a goat with joint, lung and kidney lesions similar to those associated with the caprine arthritis-encephalitis complex [5].

High impact information on Visna-Maedi Virus

• We have characterized the properties of the maedi-visna virus (MVV) glycoprotein, which has a long cytoplasmic C-terminal domain, and of a panel of C-terminally truncated and C-terminally chimeric MVV-Env constructs [6].
• Our findings show that the maedi-visna virus tat gene product contributes to the pathogenesis of multiorgan proliferative disorders associated with maedi-visna virus infection [7].
• In order to analyse the pattern of sequence variation in maedi-visna virus (MVV) in persistently infected sheep and to answer the question of whether antigenic variants are selected in a long-term MVV infection, an 87 bp variable region in the env gene of ten antigenic variants and 24 non-variants was sequenced [8].
• Overall, at least six different clades could be differentiated, with no clear separation of SRLV strains derived from goats (caprine arthritis-encephalitis virus) or sheep (maedi-visna virus) [9].
• Surprisingly, these sequences have a higher identity (of nucleotide and derived amino acid sequences) to caprine arthritis-encephalitis virus than to the ovine prototype, maedi-visna virus [10].

Chemical compound and disease context of Visna-Maedi Virus

• Neurotoxic mechanisms of transactivating protein Tat of Maedi-Visna virus [11].
• Static lung compliance, static lung volumes, and transfer factor for carbon monoxide were measured in 12 anesthetized adult Texel ewes seropositive for maedi-visna virus (MVV) and in 11 breed-, sex-, and age-matched seronegative controls [12].
• An enzyme-linked immunosorbent assay for detection of antibodies to maedi-visna virus in sheep. I. A simple technique for production of antigen using sodium dodecyl sulfate treatment [13].

Biological context of Visna-Maedi Virus

• Gene gun mucosal DNA immunization of sheep with a plasmid expressing the env gene of Maedi-Visna virus (MVV) was used to examine the protection against MVV infection in sheep from a naturally infected flock [14].

Anatomical context of Visna-Maedi Virus

• Alveolar macrophages from sheep naturally infected by visna-maedi virus contribute to IL-8 production in the lung [15].

Gene context of Visna-Maedi Virus

• Neurotoxicity of peptide analogues of the transactivating protein tat from Maedi-Visna virus and human immunodeficiency virus [1].
• Comparative studies of bacterially expressed integrase proteins of caprine arthritis-encephalitis virus, maedi-visna virus and human immunodeficiency virus type 1 [16].
• Mucosal immunization of sheep with a Maedi-Visna virus (MVV) env DNA vaccine protects against early MVV productive infection [14].
• Synthetic peptides 10 to 14 amino acids in length were selected from HSRV (3), maedi-visna virus (1), human nerve growth factor-beta (1), and human amyloid-beta sequences (1) [17].
• Expression of maedi-visna virus major core protein, p25: development of a sensitive p25 antigen detection assay [18].

Analytical, diagnostic and therapeutic context of Visna-Maedi Virus

• The gene for the major core protein, p25, of maedi-visna virus (MVV) was cloned using a PCR (polymerase chain reaction) strategy employing primers designed for the insertion of the gene directly into yeast Ty-VLP expression vectors [18].
• Using neutralization of the viral reverse transcriptase and an enzyme immunoassay as criteria, no serological relationship could be demonstrated to representatives of type B, C and C oncoviruses, or to bovine leukemia virus, maedi-visna virus of sheep or caprine arthritis-encephalitis virus [19].
• Maedi-visna virus and caprine arthritis-encephalitis virus: distinct species or quasispecies and its implications for laboratory diagnosis [20].

References