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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Health Services Accessibility

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Disease relevance of Health Services Accessibility

  • Among 1,102 recent Escherichia coli clinical isolates, clonal group A was identified in 17 of 20 (U.S. and non-U.S.) geographic locales, mainly among U.S. isolates (9% vs. 3%; p < 0.001) and those resistant to trimethoprim-sulfamethoxazole (10% vs. 1.7%; p < 0.001) [1].
  • The Nagahata M gene is strikingly similar to the M gene of Biken strain SSPE virus isolated several years later in the same locale [2].
  • p53 mutational spectrum of esophageal carcinomas from five different geographical locales in China [3].
  • In two recent cases of osteitis fibrosa cystica (OFC), however, patients without adequate access to health care served as graphic reminders that the clinical spectrum of the disease includes bone disease, and that OFC can be the presenting manifestation of long-standing primary hyperparathyroidism [4].
  • Other work has suggested that one or more of these locales may play a more pronounced role in glutamate-mediated toxicity [5].

Psychiatry related information on Health Services Accessibility


High impact information on Health Services Accessibility

  • Therefore, a single TrkA effector, PI3-K, has multiple roles within spatially distinct cellular locales during retrograde NGF signaling [7].
  • Access to health care in the Western Cape [8].
  • Both NH2- and COOH-terminal mutants retained insulin-dependent movement from an intracellular to a cell surface locale, suggesting that neither of these motifs is involved in the insulin-dependent redistribution of GLUT-4 [9].
  • Insulin-activated glucose transport depends on the efficient sorting of facilitated hexose transporter isoforms to distinct subcellular locales [10].
  • The ubiquitin-proteasome system (UPS) plays a vital role in directing molecules to the 26S proteasome for degradation as well as other locales in the cell [11].

Chemical compound and disease context of Health Services Accessibility

  • SETTING: Rural lowland region of Nepal. SUBJECTS: One hundred and fifty-six children (aged 1-6 y old), half of whom previously had xerophthalmia due to vitamin A-deficiency, the other half matched by locale, age and the presence and age of a younger sibling (n = 102) [12].
  • CONCLUSION: Many Americans actively sought prophylaxis with ciprofloxacin during the course of the October 2001 anthrax attack and that utilization was higher in, but not limited to, locales with publicized cases of disease [13].

Biological context of Health Services Accessibility


Anatomical context of Health Services Accessibility


Associations of Health Services Accessibility with chemical compounds

  • We report here the cell surface locale where the trafficking of HDL cholesterol occurs [23].
  • The fact that the latter is more than 1 order of magnitude larger than its value obtained in a homogeneous acetonitrile solution suggests that the structure and locale of the Os(DPP)3(III+/II+) monolayer system result in a larger electronic coupling and/or smaller reorganization energy [24].
  • Evidence is presented that in clinical pneumococcal isolates, penicillin-binding proteins (PBPs) groups 1 and 2 have a decreased affinity for radioactive benzylpenicillin as compared with penicillin-sensitive isolates from the same locale [25].
  • 2-substituted derivatives of adenosine and inosine cyclic 3',5'-phosphate. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase [26].
  • 1. The reduction of mitochondrial NAD(P) by 2-oxoglutarate was monitored as a measure of 2-oxoglutarate dehydrogenase activity in its intramitochondrial locale [27].

Gene context of Health Services Accessibility

  • We now employ cell engineering approaches to control localization of the upstream EGFR and ERK activities to examine the spatial effect of upstream signal locale on downstream calpain activity [28].
  • Together, these findings suggest a role for PLD1 as a signaling node, in which integration of convergent signals occurs within discrete locales of the cellular membrane [29].
  • In the adult gut, MIA and MIB both exhibit a microvillar component as MIA attains a more apical position in addition to its previous terminal web locale [30].
  • MGMT was found both in the cytoplasm and the nucleus, and in either locale the protein reacts with alkylated DNA bases and becomes inactivated and lost from the cell [31].
  • Quantitative genetic analysis of hepatic and splenic iron levels in recombinant inbred mice yielded a quantitative trait locus that was found to coincide with the genomic locale encompassing the tumor necrosis factor receptor 2 gene (Tnfr2) [32].

Analytical, diagnostic and therapeutic context of Health Services Accessibility

  • In 2001, Médicins Sans Frontières conducted a survey in five areas of western and central DRC to assess mortality, access to health-care, vaccination coverage and exposure to violence [33].


  1. Distribution and characteristics of Escherichia coli clonal group A. Johnson, J.R., Murray, A.C., Kuskowski, M.A., Schubert, S., Prère, M.F., Picard, B., Colodner, R., Raz, R. Emerging Infect. Dis. (2005) [Pubmed]
  2. Role of biased hypermutation in evolution of subacute sclerosing panencephalitis virus from progenitor acute measles virus. Wong, T.C., Ayata, M., Ueda, S., Hirano, A. J. Virol. (1991) [Pubmed]
  3. p53 mutational spectrum of esophageal carcinomas from five different geographical locales in China. Lung, M.L., Chan, W.C., Zong, Y.S., Tang, C.M., Fok, C.L., Wong, K.T., Chan, L.K., Lau, K.W. Cancer Epidemiol. Biomarkers Prev. (1996) [Pubmed]
  4. Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. Bassler, T., Wong, E.T., Brynes, R.K. Am. J. Clin. Pathol. (1993) [Pubmed]
  5. NMDA sensitivity is neurite enhanced. Heng, J.E., Moscaritolo, K., Dreyer, E.B. Neuroreport (1995) [Pubmed]
  6. "Trade-off" between medical cost controls and quality of care? Maybe, maybe not! Part II. Varney, R.A., Schroeder, D.J. Journal of quality assurance : a publication of the National Association of Quality Assurance Professionals. (1990) [Pubmed]
  7. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Kuruvilla, R., Ye, H., Ginty, D.D. Neuron (2000) [Pubmed]
  8. Access to health care in the Western Cape. Cummins, P. Lancet (2002) [Pubmed]
  9. Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes. Marsh, B.J., Alm, R.A., McIntosh, S.R., James, D.E. J. Cell Biol. (1995) [Pubmed]
  10. Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells. Hudson, A.W., Fingar, D.C., Seidner, G.A., Griffiths, G., Burke, B., Birnbaum, M.J. J. Cell Biol. (1993) [Pubmed]
  11. Neurological disease: UPS stops delivering! Miller, R.J., Wilson, S.M. Trends Pharmacol. Sci. (2003) [Pubmed]
  12. Infant feeding practices reflect antecedent risk of xerophthalmia in Nepali children. Gittelsohn, J., Shankar, A.V., West, K.P., Ram, R., Dhungel, C., Dahal, B. European journal of clinical nutrition. (1997) [Pubmed]
  13. Changes in ciprofloxacin utilization as shown in a large pharmacy claims database: effects of proximity to criminal anthrax exposure in October 2001. Brinker, A., Pamer, C., Beitz, J. Journal of the American Pharmacists Association : JAPhA. (2003) [Pubmed]
  14. Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. Gong, W., Russell, M., Suzuki, K., Riabowol, K. Mol. Cell. Biol. (2006) [Pubmed]
  15. Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor. Wessendorf, J.H., Garfinkel, S., Zhan, X., Brown, S., Maciag, T. J. Biol. Chem. (1993) [Pubmed]
  16. The monovalent ionophore monensin maintains the nuclear localization of the human stress protein hsp28 during heat shock recovery. Arrigo, A.P. J. Cell. Sci. (1990) [Pubmed]
  17. Access to health care in the United States: barriers for neurologic patients, challenges for neurologic physicians. Earnest, M.P. Neurology (1990) [Pubmed]
  18. Sequence diversity within the reovirus S3 gene: reoviruses evolve independently of host species, geographic locale, and date of isolation. Goral, M.I., Mochow-Grundy, M., Dermody, T.S. Virology (1996) [Pubmed]
  19. Estrogen receptors in the spinal cord, sensory ganglia, and pelvic autonomic ganglia. Papka, R.E., Mowa, C.N. Int. Rev. Cytol. (2003) [Pubmed]
  20. Vagal afferents from the uterus and cervix provide direct connections to the brainstem. Collins, J.J., Lin, C.E., Berthoud, H.R., Papka, R.E. Cell Tissue Res. (1999) [Pubmed]
  21. Mechanism of protein kinase CK2 association with nuclear matrix: role of disulfide bond formation. Zhang, P., Davis, A.T., Ahmed, K. J. Cell. Biochem. (1998) [Pubmed]
  22. Eimeria acervulina: DNA cloning and characterization of recombinant sporozoite and merozoite antigens. Jenkins, M.C., Lillehoj, H.S., Dame, J.B. Exp. Parasitol. (1988) [Pubmed]
  23. Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein. Peng, Y., Akmentin, W., Connelly, M.A., Lund-Katz, S., Phillips, M.C., Williams, D.L. Mol. Biol. Cell (2004) [Pubmed]
  24. 2D electrochemical time of flight and its application in the measurements of the kinetics of lateral electron hopping in monolayer films at the air/water interface. Wittek, M., Möller, G., Johnson, M.J., Majda, M. Anal. Chem. (2001) [Pubmed]
  25. Alterations in penicillin-binding proteins of clinical and laboratory isolates of pathogenic Streptococcus pneumoniae with low levels of penicillin resistance. Handwerger, S., Tomasz, A. J. Infect. Dis. (1986) [Pubmed]
  26. 2-substituted derivatives of adenosine and inosine cyclic 3',5'-phosphate. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase. Meyer, R.B., Uno, H., Robins, R.K., Simon, L.N., Miller, J.P. Biochemistry (1975) [Pubmed]
  27. Effects of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate. Hansford, R.G., Castro, F. Biochem. J. (1981) [Pubmed]
  28. Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling. Glading, A., Uberall, F., Keyse, S.M., Lauffenburger, D.A., Wells, A. J. Biol. Chem. (2001) [Pubmed]
  29. Kinetic analysis of a mammalian phospholipase D: allosteric modulation by monomeric GTPases, protein kinase C, and polyphosphoinositides. Henage, L.G., Exton, J.H., Brown, H.A. J. Biol. Chem. (2006) [Pubmed]
  30. Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Morgan, N.S., Heintzelman, M.B., Mooseker, M.S. Dev. Biol. (1995) [Pubmed]
  31. Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase. Belanich, M., Randall, T., Pastor, M.A., Kibitel, J.T., Alas, L.G., Dolan, M.E., Schold, S.C., Gander, M., Lejeune, F.J., Li, B.F., White, A.B., Wasserman, P., Citron, M.L., Yarosh, D.B. Cancer Chemother. Pharmacol. (1996) [Pubmed]
  32. Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway? Meyer, P.N., Gerhard, G.S., Yoshida, Y., Yoshida, M., Chorney, K.A., Beard, J., Kauffman, E.J., Weiss, G., Chorney, M.J. Blood Cells Mol. Dis. (2002) [Pubmed]
  33. Mortality, violence and lack of access to healthcare in the Democratic Republic of Congo. Van Herp, M., Parqué, V., Rackley, E., Ford, N. Disasters. (2003) [Pubmed]
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