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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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van der Houven van Oordt, C.W. et al.

Differentially expressed transcripts in X-ray-induced lymphomas identified by dioxygenin-labeled differential display.

Differential display is an easily applied method for comparing gene expression in a variety of systems. We used a nonradioactive differential display technique to analyze X-ray-induced lymphomas derived from Emu-pim-1 transgenic and nontransgenic mice. Fragments of 11 differentially regulated genes were identified, three of which are novel sequences. One of the cloned fragments contained sequences of a mouse VL30 retroelement that was significantly overexpressed in a subset of lymphomas as compared with non-lymphomatous tissue. Interestingly, these lymphomas also displayed high levels of c-myc transcripts. An altered expression pattern of a glutathione S-transferase homologue was identified in several lymphomas. Moreover, a cytotoxic T-lymphocyte lipase appeared to be overexpressed specifically in lymphoma-containing spleen tissue, and the results suggest that it may be related to the endogenous immune response against lymphoma development.[1]

References

Differentially expressed transcripts in X-ray-induced lymphomas identified by dioxygenin-labeled differential display. van der Houven van Oordt, C.W., Schouten, T.G., van der Eb, A.J., Breuer, M.L. Mol. Carcinog. (1999) [Pubmed]

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