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Kesler, D.J. et al.

Kesler, Summers, Peterson, Steckler,

Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine.

Two experiments were conducted with bulls administered norgestomet and gonadorelin to determine if the gonadorelin-induced release of testosterone could be developed into a biological assay for quality assurance of gonadorelin. Implants containing norgestomet (0 to 36 mg) reduced the episodic release (r = -.81; P < .05) and mean concentrations of testosterone (r = -.82; P < .05). Gonadoreline-induced testosterone release increased (r = .99; P < .05) with increasing dosage of gonadorelin (up to 5 micrograms) in norgestomet-implanted bulls (36 mg). Maximal testosterone was released (> sixfold increase) with 5 to 40 micrograms of gonadorelin. In summary, the gonadorelin-induced testosterone release in bulls administered a synthetic progestin is a sensitive (0.008 microgram per kg body weight for 5 micrograms of gonadorelin) biological assay with a rapid turnaround time for the confirmation of gonadorelin potency. Based on a per-kg-body-weight basis, the norgestomet-treated bull is the most sensitive biological assay model.[1]

References

Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine. Kesler, D.J., Summers, R.N., Peterson, C.A., Steckler, T.L. Drug development and industrial pharmacy. (1999) [Pubmed]

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