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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Roose, J. et al.

Roose, Korver, de Boer, Kuipers, Hurenkamp, Clevers,

The Sox-13 gene: structure, promoter characterization, and chromosomal localization.

We have recently identified the HMG box transcription factor Sox-13 and described its expression during murine embryogenesis. Here we describe the structure of the murine Sox-13 gene. This gene spans approximately 12 kb and consists of 13 exons. The HMG domain is encoded by exons XI and XII, separated by an intron that is conserved among Sox-5, Sox-13, and Sox-17. A single major transcription initiation site was identified. Deletion analysis of the 3-kb promoter region revealed a 400-bp fragment driving transcription of a luciferase reporter in a Sox-13-expressing cell line. To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolated with 75% homology to the mouse Sox-13. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32.[1]

References

The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Roose, J., Korver, W., de Boer, R., Kuipers, J., Hurenkamp, J., Clevers, H. Genomics (1999) [Pubmed]

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