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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase.

Different Drosophila photoreceptors (R cells) connect to neurons in different optic lobe layers. R1-R6 axons project to the lamina; R7 and R8 axons project to separate layers of the medulla. We show a receptor tyrosine phosphatase, PTP69D, is required for lamina target specificity. In Ptp69D mutants, R1-R6 project through the lamina, terminating in the medulla. Genetic mosaics, transgene rescue, and immunolocalization indicate PTP69D functions in R1-R6 growth cones. PTP69D overexpression in R7 and R8 does not respecify their connections, suggesting PTP69D acts in combination with other factors to determine target specificity. Structure-function analysis indicates the extracellular fibronectin type III domains and intracellular phosphatase activity are required for targeting. We propose PTP69D promotes R1-R6 targeting in response to extracellular signals by dephosphorylating substrate(s) in R1-R6 growth cones.[1]

References

  1. Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Garrity, P.A., Lee, C.H., Salecker, I., Robertson, H.C., Desai, C.J., Zinn, K., Zipursky, S.L. Neuron (1999) [Pubmed]
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