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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin.

The mechanism of the positive cardioactive effects induced by verbascoside in the Lagendorff rat heart has been investigated. Isolated rat hearts treated with alpha- or beta-adrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside. A significant increase in prostacyclin levels (142%) observed following the administration of verbascoside suggests that prostacyclin stimulates formation of cAMP which induces the cardioactivity associated with verbascoside.[1]

References

  1. Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin. Pennacchio, M., Syah, Y.M., Alexander, E., Ghisalberti, E.L. Phytotherapy research : PTR. (1999) [Pubmed]
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