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Chun, T.W. et al.

Chun, Engel, Mizell, Hallahan, Fischette, Park, Davey, Dybul, Kovacs, Metcalf, Mican, Berrey, Corey, Lane, Fauci,

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy.

The size of the pool of resting CD4+ T cells containing replication-competent HIV in the blood of patients receiving intermittent interleukin (IL)-2 plus highly active anti-retroviral therapy (HAART) was significantly lower than that of patients receiving HAART alone. Virus could not be isolated from the peripheral blood CD4+ T cells in three patients receiving IL-2 plus HAART, despite the fact that large numbers of resting CD4+ T cells were cultured. Lymph node biopsies were done in two of these three patients and virus could not be isolated. These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV.[1]

References

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Chun, T.W., Engel, D., Mizell, S.B., Hallahan, C.W., Fischette, M., Park, S., Davey, R.T., Dybul, M., Kovacs, J.A., Metcalf, J.A., Mican, J.M., Berrey, M.M., Corey, L., Lane, H.C., Fauci, A.S. Nat. Med. (1999) [Pubmed]

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