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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level.

The effects of Panax ginseng on morphine-induced immune suppression were studied. Morphine (20 mg/kg, SC, 4 days) decreased body weight increment rate and caused atrophy of thymus and spleen. These changes were partly reversed by concomitant administration of ginseng total saponin (GTS, 100 mg/kg, oral, 9 days). Morphine elevated the serum corticosterone level and caused the DNA fragmentation of thymocytes. These sequential events were completely blocked by a concomitant administration of GTS. Flow cytometry analysis showed that GTS specifically blocked morphine-induced apoptosis of thymocytes.[1]

References

  1. Panax ginseng blocks morphine-induced thymic apoptosis by lowering plasma corticosterone level. Kim, Y.R., Lee, S.Y., Shin, B.A., Kim, K.M. Gen. Pharmacol. (1999) [Pubmed]
 
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