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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Therapeutic antibodies elicited by immunization against TNF-alpha.

Tumor necrosis factor-alpha (TNF-alpha) is critically involved in the pathogenesis of several chronic inflammatory diseases. Monoclonal antibodies against TNF-alpha are currently used for the treatment of rheumatoid arthritis and Crohn's disease. This report describes a simple and effective method for active immunization against self TNF-alpha. This vaccination approach leads to a T-cell-dependent polyclonal and sustainable anti-TNF-alpha autoantibody response that declines upon discontinuation of booster injections. The autoantibodies are elicited by injecting modified recombinant TNF-alpha molecules containing foreign immunodominant T-helper epitopes. In mice immunized with such molecules, the symptoms of experimental cachexia and type II collagen-induced arthritis are ameliorated. These results suggest that vaccination against TNF-alpha may be a useful approach for the treatment of rheumatoid arthritis and other chronic inflammatory diseases.[1]


  1. Therapeutic antibodies elicited by immunization against TNF-alpha. Dalum, I., Butler, D.M., Jensen, M.R., Hindersson, P., Steinaa, L., Waterston, A.M., Grell, S.N., Feldmann, M., Elsner, H.I., Mouritsen, S. Nat. Biotechnol. (1999) [Pubmed]
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