Bombyxin exhibits an insulin-like response to modification in the N-terminal region of the A chain.
Bombyxin is an insect neurohormone with an insulin-like structure. The N-terminal A chain helix, a region which is considered part of the active site in insulin, is almost identical between the two hormones. Bombyxin analogues with modifications at the N-terminus of the A-chain were synthesized and investigated for their ability to bind to bombyxin-specific receptors. While N-acetylation reduced the affinity to the bombyxin receptor to 18% the removal of glycine (A1) inactivated the hormone completely. Replacement of glycine (A1) by L-amino acids caused a significant loss in activity (11%) while its replacement by D-amino acid resulted in active bombyxin analogues (55%). Comparative CD spectroscopy indicated a change in structure for desGly(A1)bombyxin. Although the insect hormone does not have an insulin-like function it exhibits mammalian insulin-like structural sensitivity for A chain modifications.[1]References
- Bombyxin exhibits an insulin-like response to modification in the N-terminal region of the A chain. Büllesbach, E.E. J. Pept. Res. (1999) [Pubmed]
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