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Interleukin-12, interferon-gamma and interleukin-4 gene expression in cats infected with Toxoplasma gondii.

Interleukin-12, Interferon-gamma and Interleukin-4 mRNA levels in cells of the spleen and mesenteric lymph nodes of cats following primary and secondary infection with Toxoplasma gondii were examined by a semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) method. Expression of Interleukin-12p40 mRNA and Interferon-gamma mRNA was observed after primary and secondary oral infection with Toxoplasma gondii. In contrast, no expression of IL-4 mRNA in the spleen and little expression in the mesenteric lymph nodes were observed after primary infection when the cats shed oocysts, however, the expression of IL-4 mRNA observed in the cats after secondary inoculation.[1]

References

  1. Interleukin-12, interferon-gamma and interleukin-4 gene expression in cats infected with Toxoplasma gondii. Koyama, T., Omata, Y., Maki, Y., Toyoda, Y., Saito, A. J. Vet. Med. Sci. (1999) [Pubmed]
 
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