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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia.

Mutations in the Pfmdr1 gene are reported to be associated with chloroquine resistance in some Plasmodium falciparum isolates. A polymerase chain reaction/restriction fragment length polymorphism method was used for the detection of Pfmdr1 mutations in chloroquine-resistant field isolates of P. falciparum collected in Irian Jaya. The frequency of Pfmdr1 mutations was significantly higher in chloroquine-resistant P. falciparum parasites than background frequencies observed in the same location. The 7G8 mutation was identified in some parasites although always in a mixed genotype status. Chloroquine-resistant P. falciparum specimens were characterized using the World Health Organization 28-day criteria, supplemented by demonstrating adequate chloroquine absorption and genetic analysis.[1]

References

  1. Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia. Gómez-Saladín, E., Fryauff, D.J., Taylor, W.R., Laksana, B.S., Susanti, A.I., Purnomo, n.u.l.l., Subianto, B., Richie, T.L. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
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