- The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice. Aoki, K., Didomenico, E., Sims, N.A., Mukhopadhyay, K., Neff, L., Houghton, A., Amling, M., Levy, J.B., Horne, W.C., Baron, R. Bone (1999)