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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity.

A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3-Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.[1]

References

  1. Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity. Ahmad, W., De Fusco, M., ul Haque, M.F., Aridon, P., Sarno, T., Sohail, M., ul Haque, S., Ahmad, M., Ballabio, A., Franco, B., Casari, G. Eur. J. Hum. Genet. (1999) [Pubmed]
 
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