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Tavío, M.M. et al.

Tavío, Vila, Ruiz, Ruiz, Martín-Sánchez, Jiménez de Anta,

Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates.

Eighteen quinolone-resistant isolates of Escherichia coli were selected by exposing ten clinical isolates to increasing concentrations of norfloxacin and lomefloxacin. The mutant isolates showed a multiple-antibiotic-resistance phenotype. All of them contained single mutations in gyrA consisting of the substitution of Ser-83-->Leu (n = 14), Val (n = 1) or Ala (n = 1) and the substitution of Asp-87-->Asn (n = 2). Only one concomitant mutation in parC (Ser-80-->Arg) was detected. Four parent isolates exhibited a single mutation in gyrA which required < or = 12 mg/L of norfloxacin to be inhibited. Fluoroquinolone resistance, in the 18 quinolone-resistant mutants, was a result of mutations affecting DNA gyrase plus decreased fluoroquinolone uptake. This latter mechanism of resistance was a combined effect of an absence of OmpF and an increase in active efflux in eight isolates, or an increased active efflux alone in the remaining ten selected mutants.[1]

References

Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates. Tavío, M.M., Vila, J., Ruiz, J., Ruiz, J., Martín-Sánchez, A.M., Jiménez de Anta, M.T. J. Antimicrob. Chemother. (1999) [Pubmed]

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