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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity.

8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.[1]

References

  1. Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity. Jew, S.S., Yoo, C.H., Lim, D.Y., Kim, H., Mook-Jung, I., Jung, M.W., Choi, H., Jung, Y.H., Kim, H., Park, H.G. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
 
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