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Centrally administered neurotensin: activity in the Julou-Courvoisier muscle relaxation test in mice.

Intracisternal (IC) neurotensin ( NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects on NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.[1]

References

  1. Centrally administered neurotensin: activity in the Julou-Courvoisier muscle relaxation test in mice. Osbahr, A.J., Nemeroff, C.B., Manberg, P.J., Prange, A.J. Eur. J. Pharmacol. (1979) [Pubmed]
 
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