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Greinix, H.T. et al.

Greinix, Linkesch, Seifert, Kubista, Czerwenka, Elahi, Zielinski, Hoecker, Steger, Schulenburg, Neumeister, Rabitsch, Jakesz, Kalhs,

Paclitaxel-containing high-dose chemotherapy in high-risk breast cancer patients.

Despite standard-dose adjuvant chemotherapy, the prognosis for patients with breast cancer and extensive axillary lymph node involvement at diagnosis is poor. The efficacy of a paclitaxel-containing, high-dose chemotherapy protocol in 21 high-risk breast cancer patients is assessed. After standard-dose chemotherapy followed by peripheral blood stem cell (PBSC) mobilization, high-dose therapy with paclitaxel, carboplatin, and cyclophosphamide and CD34-selected PBSC rescue was given. Hematologic reconstitution after high-dose therapy was rapid. Main toxicity included diarrhea grade I or II in about half of the patients and infections were observed in 19%. Five-year probabilities for relapse and failure-free survival were 32% and 62%, respectively. High-dose consolidation with paclitaxel, carboplatin, and cyclophosphamide achieves a high failure-free survival in patients with high-risk breast cancer with acceptable toxicities and stable, long-term hematopoietic reconstitution. Evaluation of the benefit of high-dose therapy in these patients in larger prospective, randomized trials is warranted and currently under way.[1]

References

Paclitaxel-containing high-dose chemotherapy in high-risk breast cancer patients. Greinix, H.T., Linkesch, W., Seifert, M., Kubista, E., Czerwenka, K., Elahi, F., Zielinski, C., Hoecker, P., Steger, G., Schulenburg, A., Neumeister, G., Rabitsch, W., Jakesz, R., Kalhs, P. Acta oncologica (Stockholm, Sweden) (2000) [Pubmed]

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