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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a Forkhead factor that regulates longevity in Caenorhabditis elegans. Here we show that overexpression of these Forkhead transcription factors causes growth suppression in a variety of cell lines, including a Ras-transformed cell line and a cell line lacking the tumour suppressor PTEN. Expression of AFX blocks cell-cycle progression at phase G1, independent of functional retinoblastoma protein ( pRb) but dependent on the cell-cycle inhibitor p27kip1. Indeed, AFX transcriptionally activates p27kip1, resulting in increased protein levels. We conclude that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation.[1]

References

  1. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Medema, R.H., Kops, G.J., Bos, J.L., Burgering, B.M. Nature (2000) [Pubmed]
 
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