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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of genetic and diet-induced obesity on lipid metabolism.

C57BL/6J obese ( ob/ ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard (Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) body weight in this 34-day period than that of the other two groups fed on the Normal diet. Epididymal fat depot and adipocyte cell size were significantly larger (P<0.05) in the Lard-fed lean mice and in the obese ( ob/ ob) mice than were those of the Normal-fed lean mice. Dietary Lard intake did not significantly affect concentrations of plasma triglyceride although those of plasma cholesterol were significantly increased (P<0.05). The development of obesity in these Lard-fed mice appeared to be accelerated and significant.[1]

References

  1. Effects of genetic and diet-induced obesity on lipid metabolism. Libinaki, R., Heffernan, M., Jiang, W.J., Ogru, E., Ignjatovic, V., Gianello, R., Trickey, L., Taylor, M., Ng, F. IUBMB Life (1999) [Pubmed]
 
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