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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.

We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.[1]

References

  1. No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder. Goossens, D., Villafuerte, S., Tissir, F., Van Gestel, S., Claes, S., Souery, D., Massat, I., Van den Bossche, D., Van Zand, K., Mendlewicz, J., Van Broeckhoven, C., Del-Favero, J. Eur. J. Hum. Genet. (2000) [Pubmed]
 
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