How cystic fibrosis affects pancreatic ductal bicarbonate secretion

Med Clin North Am. 2000 May;84(3):641-55, x. doi: 10.1016/s0025-7125(05)70247-9.

Abstract

Pancreatic bicarbonate secretion is impaired in patients with cystic fibrosis. This article reviews recent advances in bicarbonate dependent transporters in pancreatic duct cells and discusses their regulation in cystic fibrosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acid-Base Equilibrium / genetics
  • Acid-Base Equilibrium / physiology*
  • Animals
  • Bicarbonates / metabolism*
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / physiopathology*
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Cystic Fibrosis Transmembrane Conductance Regulator / physiology
  • Pancreatic Ducts / metabolism*
  • Secretin / physiology

Substances

  • Bicarbonates
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Secretin