Survey for the presence and distribution of human herpesvirus 8 in healthy brain

J Clin Microbiol. 2000 Jul;38(7):2772-3. doi: 10.1128/JCM.38.7.2772-2773.2000.

Abstract

Brain tissues from both sides of the cerebellum and frontal, temporal, parietal, and occipital lobes were collected postmortem from 30 patients for human herpesvirus 8 (HHV-8) detection by PCR. Overall, 42 of 300 (14.0%) samples were positive, with similar rates for each position. Nineteen patients (63.3%) were positive and showed a significant increase in positivity with age (P = 0.007). The results indicate a neuroinvasive and neuropersistent potential of HHV-8.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autopsy
  • Brain / virology*
  • DNA, Viral / analysis
  • Female
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction

Substances

  • DNA, Viral