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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hoyer-Fender, S. et al.

Hoyer-Fender, Costanzi, Pehrson,

Histone macroH2A1.2 is concentrated in the XY-body by the early pachytene stage of spermatogenesis.

The pairing of sex chromosomes during meiosis in male mammals is associated with ongoing heterochromatinization and X inactivation. This process occurs in a specific area of the nucleus that can be discerned morphologically: the sex vesicle or XY-body. In contrast to X inactivation in the somatic cells of female mammals the reasons for X inactivation in the male germline remain obscure. We have recently demonstrated that the inactive X chromosome in somatic cells of female mammals is marked by a high concentration of histone macroH2A. Here we investigate X inactivation in the meiotic cells of the male germline. We demonstrate here that macroH2A1.2 is present in the nuclei of germ cells starting first with localization that is largely, if not exclusively, to the developing XY-body in early pachytene spermatocytes. Our results suggest that inactivation of sex chromosomes in the male germ cell includes a major alteration of the nucleosomal structure.[1]

References

Histone macroH2A1.2 is concentrated in the XY-body by the early pachytene stage of spermatogenesis. Hoyer-Fender, S., Costanzi, C., Pehrson, J.R. Exp. Cell Res. (2000) [Pubmed]

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