H(2) antagonist nizatidine may control olanzapine-associated weight gain in schizophrenic patients.
BACKGROUND: Olanzapine is temporally associated, in a number of patients with schizophrenia, with weight gain. H(2) antagonists, like nizatidine, have been shown to control appetite in overweight patients. METHODS: A patient with olanzapine temporally associated weight gain was treated with nizatidine as "add-on" therapy. RESULTS: Nizatidine treatment was associated with good control and subsequent reduction of weight after 4 to 5 weeks of therapy in a patient with repetitive episodes of weight gain during olanzapine treatment. Olanzapine was otherwise well tolerated and effective in controlling psychopathology. CONCLUSIONS: H(2) antagonist treatment with olanzapine may be a valid medical strategy in preventing and/or reducing weight gain in patients with schizophrenia. Controlled studies are recommended to confirm this observation.[1]References
- H(2) antagonist nizatidine may control olanzapine-associated weight gain in schizophrenic patients. Sacchetti, E., Guarneri, L., Bravi, D. Biol. Psychiatry (2000) [Pubmed]
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