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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Successful trovafloxacin prophylaxis against experimental streptococcal aortic valve endocarditis.

Single-dose trovafloxacin (15 mg/kg given intravenously [i.v.]) and ampicillin (40 mg/kg given i.v.) protected 38 and 33% of animals challenged with an ampicillin-tolerant strain of Streptococcus oralis, respectively. As a double-dose regimen, trovafloxacin afforded total protection (100%; P < 0.001 versus controls). Trovafloxacin is the first fluoroquinolone effective in preventing experimental streptococcal endocarditis.[1]

References

  1. Successful trovafloxacin prophylaxis against experimental streptococcal aortic valve endocarditis. Katsarolis, I., Pefanis, A., Iliopoulos, D., Siaperas, P., Karayiannakos, P., Giamarellou, H. Antimicrob. Agents Chemother. (2000) [Pubmed]
 
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