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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effect of the aminosteroid U73122 on prostaglandin E(2) production in a murine clonal osteoblast-like cell line, MC3T3-E1.

Prostaglandin E(2) production stimulated by various agents (arachidonic acid, prostaglandin F(2alpha), ionomycin, the calcium ionophore A23187, and melittin) was investigated after pretreatment of murine osteoblast-like MC3T3-E1 cells with the putative phospholipase C blocker, U73122. The aminosteroid dose dependently inhibited prostaglandin E(2) production induced by all agonists, except arachidonic acid. The results suggest an inhibitory role of U73122 on phospholipase A(2) activity or activation.[1]

References

  1. Effect of the aminosteroid U73122 on prostaglandin E(2) production in a murine clonal osteoblast-like cell line, MC3T3-E1. Leis, H.J., Köfeler, H., Raspotnig, G., Zach, D., Fauler, G., Windischhofer, W. Biochem. Pharmacol. (2000) [Pubmed]
 
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