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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Drosophila projectin: a look at protein structure and sarcomeric assembly.

The large projectin protein is found in all Drosophila muscles; however, it shows a dual sarcomeric localization depending on the muscle type. In larval and adult synchronous muscles, projectin is found localized over the A-band. Initial in vitro binding assays indicate interactions of several projectin regions with themselves and myosin heavy chain. These interactions might be critical for the assembly of projectin over the myosin filament during embryonic myofibrillogenesis and larval growth. On the other hand, projectin localizes over the I-Z-I region in indirect flight muscles. Correspondingly, projectin is found in association with forming Z-bands during pupation and colocalizes with alpha-actinin and kettin.[1]

References

  1. Drosophila projectin: a look at protein structure and sarcomeric assembly. Ayme-Southgate, A., Southgate, R., McEliece, M.K. Adv. Exp. Med. Biol. (2000) [Pubmed]
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