Abstract
Poloxamers and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Although this is a progressive, rapidly advancing field in biotechnology, the future will depend on the recognition and rectification of a range of toxicity issues, which have to be addressed but have frequently been ignored until now.
MeSH terms
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Adjuvants, Immunologic / chemistry
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Animals
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Artificial Organs
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Biocompatible Materials
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Biomedical Engineering*
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Cell Membrane
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Complement Activation
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Drug Carriers
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Drug Resistance, Multiple
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Ethylenediamines
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Humans
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Lymphocytes / metabolism
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Phagocytosis
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Poloxalene / chemistry*
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Poloxamer / chemistry*
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Spleen / metabolism
Substances
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Adjuvants, Immunologic
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Biocompatible Materials
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Drug Carriers
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Ethylenediamines
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Poloxamer
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Poloxalene