Poloxamers and poloxamines in nanoparticle engineering and experimental medicine

Trends Biotechnol. 2000 Oct;18(10):412-20. doi: 10.1016/s0167-7799(00)01485-2.

Abstract

Poloxamers and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Although this is a progressive, rapidly advancing field in biotechnology, the future will depend on the recognition and rectification of a range of toxicity issues, which have to be addressed but have frequently been ignored until now.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Animals
  • Artificial Organs
  • Biocompatible Materials
  • Biomedical Engineering*
  • Cell Membrane
  • Complement Activation
  • Drug Carriers
  • Drug Resistance, Multiple
  • Ethylenediamines
  • Humans
  • Lymphocytes / metabolism
  • Phagocytosis
  • Poloxalene / chemistry*
  • Poloxamer / chemistry*
  • Spleen / metabolism

Substances

  • Adjuvants, Immunologic
  • Biocompatible Materials
  • Drug Carriers
  • Ethylenediamines
  • Poloxamer
  • Poloxalene