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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Sawa, H. et al.

Sawa, Kouike, Okano,

Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans.

Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SWI3 and SWI2/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.[1]

References

Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. Sawa, H., Kouike, H., Okano, H. Mol. Cell (2000) [Pubmed]

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