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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes.

The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.[1]

References

  1. Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes. García, I., Pascual, A., Ballesta, S., Joyanes, P., Perea, E.J. Antimicrob. Agents Chemother. (2000) [Pubmed]
 
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