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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia.

Stimulation of astroglial glucose utilization by the Na(+)/H(+) exchanger monensin is only partially blocked by ouabain. The present studies show that monensin also raises intracellular pH in astroglia. Because increased pH stimulates phosphofructokinase activity, the ouabain-insensitive portion of the stimulation of cerebral glucose utilization (CMR(glc)) appears to be due to stimulation of glycolysis by intracellular alkalinization.[1]

References

  1. Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia. Itoh, Y., Law, M.J., Sokoloff, L. Brain Res. (2000) [Pubmed]
 
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