Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Norman, K.E. et al.

Norman, Katopodis, Thoma, Kolbinger, Hicks, Cotter, Pockley, Hellewell,

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.

Selectin-dependent rolling is the earliest observable event in the recruitment of leukocytes to inflamed tissues. Several glycoproteins decorated with sialic acid, fucose, and/or sulfate have been shown to bind the selectins. The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin- dependent rolling in vitro and in vivo. In vitro studies have suggested that PSGL-1 may also be a ligand for E- and L-selectins. To study the in vivo function of PSGL-1, without the influence of other leukocyte proteins, the authors observed the interaction of PSGL-1-coated microspheres in mouse venules stimulated to express P- and/or E-selectin. Microspheres coated with functional recombinant PSGL-1 rolled in surgically stimulated and tumor necrosis factor alpha (TNFalpha)-stimulated mouse venules. P-selectin deficiency or inhibition abolished microsphere rolling in surgically and TNFalpha-stimulated venules, whereas E-selectin deficiency or inhibition increased microsphere rolling velocity in TNFalpha-stimulated venules. The results suggest that P-selectin-PSGL-1 interaction alone is sufficient to mediate rolling in vivo and that E-selectin-PSGL-1 interaction supports slow rolling.[1]

References

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Norman, K.E., Katopodis, A.G., Thoma, G., Kolbinger, F., Hicks, A.E., Cotter, M.J., Pockley, A.G., Hellewell, P.G. Blood (2000) [Pubmed]

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