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Tsukada, H. et al.

Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene.

Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.[1]

References

Matrical inclusions induced by clofibrate in hepatic microbodies of rats fed 2-acetylaminofluorene. Tsukada, H., Mochizuki, Y., Gotoh, M. J. Natl. Cancer Inst. (1975) [Pubmed]

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