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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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McCloy, M. et al.

McCloy, Almeida, Daly, Vulliamy, Roberts, Dokal,

Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation.

Allogeneic stem cell transplantation (SCT) represents the treatment of choice for severe bone marrow (BM) failure in patients with Fanconi's anaemia ( FA). However, for FA patients developing leukaemic or myelodysplastic transformation, the results of SCT are much less encouraging. We present a 17-year-old girl with myelodysplastic transformation of FA (refractory anaemia with excess blasts) and oculocutaneous albinism, who was treated by sibling SCT using conditioning with fludarabine, cyclophosphamide (CY) and anti-lymphocyte globulin (ALG). She had rapid engraftment with no toxicity and no graft-versus-host disease (GVHD). Twenty-two months after SCT, she had 100% donor chimaerism on Southern blot analysis.[1]

References

Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation. McCloy, M., Almeida, A., Daly, P., Vulliamy, T., Roberts, I.A., Dokal, I. Br. J. Haematol. (2001) [Pubmed]

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