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Yasuda, Y. et al.

Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells.

The role of protein kinase C (PKC) and transforming growth factor (TGF)-beta in the proliferation of vascular smooth muscle cells (SMCs) under a high glucose condition was investigated. [3H]-thymidine incorporation under 20 mM glucose was significantly accelerated compared with that under 5.5 mM glucose, and this increase was inhibited by an anti-TGF-beta antibody or a PKC-beta specific inhibitor, LY333531. The amount of active and total TGF-beta1 in the conditioned media did not differ between 5.5 and 20 mM glucose. However, the expression of TGF-beta receptor type II under 20 mM glucose was significantly increased, but that of the TGF-beta receptor type I was not. This increased expression of the TGF-beta receptor type II was prevented by LY333531. These observations suggest that the increased expression of the TGF-beta receptor type II via PKC-beta plays an important role in the accelerated proliferation of SMCs under a high glucose condition, leading to the development of diabetic macroangiopathy.[1]

References

Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells. Yasuda, Y., Nakamura, J., Hamada, Y., Nakayama, M., Chaya, S., Naruse, K., Nakashima, E., Kato, K., Kamiya, H., Hotta, N. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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