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Corrective effect of clotrimazole and beta-ionol during exposure to thiophenol.

Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.[1]

References

  1. Corrective effect of clotrimazole and beta-ionol during exposure to thiophenol. Dadali, V.A., Golovanova, N.E., Pavlova, R.N., Dzhangulova, N.E., Vinogradova, V.E. Bull. Exp. Biol. Med. (2000) [Pubmed]
 
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