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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6.

The effects of dehydroepiandrosterone sulfate (DHEAS) on thymocyte apoptosis induced by dexamethasone (DEX) were investigated. Apoptosis was measured by using agarose gel electrophoresis of DNA, the terminal deoxynucleotidyltransferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay and flow cytometry. Our results showed that preincubation with 1 x 10(-4) M DHEAS protected thymocytes from DEX-induced apoptosis in vitro. Moreover, we found no blocking effect on the DEX-induced activation of caspase-3 and caspase-6 by the preincubation of thymocytes with DHEAS. This may be interpreted to mean that the antagonism of DHEAS to DEX-induced apoptosis is not related to the activation of these down-stream caspases which play a critical role in the execution of apoptosis.[1]

References

  1. The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6. Yan, C.H., Jiang, X.F., Pei, X., Dai, Y.R. Cell. Mol. Life Sci. (1999) [Pubmed]
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