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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection.

In two of 15 patients coinfected with HIV and hepatitis C virus who received interferon-alpha plus ribavirin in addition to HAART, we observed multiorgan dysfunction and lactic acidaemia. As ribavirin is a nucleoside analogue, an increased risk of mitochondrial toxicity can be induced in HIV-infected patients already treated with nucleoside analogues, leading to clinical deterioration in some cases.[1]

References

  1. Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection. Lafeuillade, A., Hittinger, G., Chadapaud, S. Lancet (2001) [Pubmed]
 
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