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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

DDT -- a novel domain in different transcription and chromosome remodeling factors.

Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.[1]

References

  1. DDT -- a novel domain in different transcription and chromosome remodeling factors. Doerks, T., Copley, R., Bork, P. Trends Biochem. Sci. (2001) [Pubmed]
 
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