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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Epidermal growth factor regulates astrocyte expression of the interleukin-4 receptor via a MAPK-independent pathway.

Human astrocytes express the interleukin (IL)-4 receptor alpha chain (IL-4R alpha) in vitro and in vivo but mechanisms governing astrocyte IL-4R alpha expression have not been established. We hypothesized that epidermal growth factor (EGF) and IL-4, agents that profoundly affect astrocyte proliferation, might also alter IL-4R alpha expression. Exposure to EGF for 24 h enhanced IL-4R alpha mRNA levels; in contrast, IL-4 yielded no increase. Immunoblotting demonstrated that EGF but not IL-4 increased astrocyte IL-4R alpha protein after 2--4 days of exposure. Similarly, EGF but not IL-4 strongly activated phosphorylation of p42/ p44 extracellular regulated kinase isoforms, a reaction blocked by the mitogen-activated protein kinase ( MAPK) inhibitor, PD98059. PD98059 also blocked EGF- stimulated DNA synthesis but not IL-4R alpha mRNA levels, while antibody to the EGF receptor (erbB1) blocked both EGF effects. Data suggest that astrocyte IL-4R alpha expression is upregulated by EGF but not by IL-4 in an EGF-receptor-dependent manner and that mechanisms are independent of MAPK activation.[1]

References

  1. Epidermal growth factor regulates astrocyte expression of the interleukin-4 receptor via a MAPK-independent pathway. Barna, B.P., Mattera, R., Jacobs, B.S., Drazba, J., Estes, M.E., Prayson, R.A., Barnett, G.H. Cell. Immunol. (2001) [Pubmed]
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