Plagiarized bacterial genes in the human book of life

Trends Genet. 2001 May;17(5):235-7. doi: 10.1016/s0168-9525(01)02282-x.

Abstract

The initial analysis of the human genome draft sequence reveals that our 'book of life' is multi-authored. A small but significant proportion of our genes owes their heritage not to antecedent eukaryotes but instead to bacteria. The publicly funded Human Genome Project study indicates that about 0.5% of all human genes were copied into the genome from bacterial sources. Detailed sequence analyses point to these 'horizontal gene transfer' events having occurred relatively recently. So how did the human 'book of life' evolve to be a chimaera, part animal and part bacterium? And what was the probable evolutionary impact of such gene plagiarism?

Publication types

  • Review

MeSH terms

  • Bacteria / genetics*
  • Human Genome Project*
  • Humans
  • Software