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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility.

The RNA encoded by the 3' untranslated region of the prohibitin gene arrests cell proliferation by blocking the transition between the G1 and S phases of the cell cycle. The product of a variant allele (T allele) is inactive. We did a case-control study of prohibitin genotype in 205 women with breast cancer and 1046 healthy controls. The results showed an association between the T allele and breast cancer in women who reported a first-degree relative with the disease (odds ratio 2.5, p=0.005). An even stronger association was found in a subset of women diagnosed at or before age 50 years (4.8, p=0.003). These data suggest that prohibitin genotyping has value in assessing risk of breast cancer in women aged 50 years or younger with at least one first-degree relative with the disease.[1]

References

  1. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Jupe, E.R., Badgett, A.A., Neas, B.R., Craft, M.A., Mitchell, D.S., Resta, R., Mulvihill, J.J., Aston, C.E., Thompson, L.F. Lancet (2001) [Pubmed]
 
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